Acupuncture for IVF
IVF and Acupuncture
Acupuncture has become popular to assist reproductive health.
Particularly many health practitioner may recommend acupuncture to you as adjunct treatment that may assist with IVF treatment.
A recent systematic review by Qian et al (2016) found that “Based on an analysis of the studies (using thirty trials (a total of 6344 participants)), acupuncture improves the clinical pregnancy rate among women undergoing IVF.
Optimal positive effects were seen when acupuncture was used during controlled ovarian hyperstimulation (Qian 2016 - SR of 30 RCTs & MA)".
Acupuncture may increase the clinical pregnancy rate and ongoing pregnancy rate and decrease the risk of ovarian hyperstimulation syndrome in women with Polycystic ovary syndrome (PCOS) undergoing IVF or intracytoplasmic sperm injection (Jo 2017 - SR of 4 RCTs & MA)
There is continuing research about how acupuncture can assist with the effectiveness of IVF treatment and you should consult your medical practitioner about how acupuncture may be able to help you.
IVF and Acupuncture Researches
Shen C, Wu M, Shu D, Zhao X, Gao Y. The role of acupuncture in in vitro fertilization: a systematic review and meta-analysis. Gynecol Obstet Invest. 2015;79(1):1-12
acupuncture did not significantly improve the IVF clinical pregnancy rate when performed only at the time of ET, while we found pooled benefit of acupuncture for IVF when performed at follicle phase and 25 min before and after ET, as well as 30 min after ET and implantation phase. (Abstract here)
Qian Y, Xia XR, Ochin H, Huang C, Gao C, Gao L, et al. Therapeutic effect of acupuncture on the outcomes of in vitro fertilization: a systematic review and meta-analysis. Arch Gynecol Obstet. 2016 Dec 19
Based on an analysis of the studies, acupuncture improves the CPR among women undergoing IVF. (Abstract here)
Jo J, Lee YJ. Effectiveness of acupuncture in women with polycystic ovarian syndrome undergoing in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis. Acupunct Med. 2017 Jan 11
Acupuncture may increase the clinical pregnancy rate and ongoing pregnancy rate and decrease the risk of ovarian hyperstimulation syndrome in women with PCOS undergoing IVF or intracytoplasmic sperm injection (Abstract here)
Effects of Acupuncture on LIF and IL-12 in Rats of Implantation Failure. American Journal of Reproductive Immunology
Pregnant rats were randomized to no treatment group (N), group that mifepristone treatment group (M), acupuncture group (A) and progestin group (P)
and leukemia inhibitory factor (LIF), LIFR protein, and mRNA in endometrium were detected.
In this research, acupuncture improved the endometrium by promotinng LIF and IL-12 secretion.
Gui, J, et al, American Journal of Reproductive Immunology, 2012 May;67(5) (Abstract here)
The relationship between perceived stress, acupuncture, and pregnancy rates among IVF patients: a pilot study,
Women undergoing Embryo transfer with or without acupuncture were observed.
Women who received acupuncture achieved pregnancy 64.7%, whereas those without acupuncture achieved pregnancy 42.5%.
Balk J, et al, Complementary Therapies in Clinical Practice, 2010 Aug;16(3):154-7 (Abstract here)
Effects of Acupuncture on pregnancy rates in Women undergoing In-vitro fertilization: A Systematic Review and Meta-analysis
This systematic review shows acupuncture improves clinical pregnancy rate (CPR) and live birth rate (LBR) among women undergoing IVF.
Cui Hong Zheng, et al, Fertility and Sterility, 2008 Mar;97(3):599-611 (Abstract here)
Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment
Prospective cohort clinical study detected that serum cortisol levels and prolactin levels in acupuncture group were significantly higher during IVF medication compared with controls.
Magarelli PC. et al, Fertil Steril, 2009 Dec;92(6):1870-9 (Abstract here)
The effect of acupuncture on outcomes in in-vitro fertilization (IVF)
116 patients received acupuncture on luteal-phase. 109 patients received placebo acupuncture.
In acupuncture group, the clinical pregnancy rate and ongoing pregnancy rate (33.6% and 28.4%, respectively) were significantly higher than placebo group (15.6% and 13.8%).
Udoff L. C. et al, Fertil Steril, 2007 Vol 86, Issue 3, pg S145 (Abstract here)
Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer
Women were randomly divided to acupuncture group and sham acupuncture group. All women had sessions on day 9, before embryo transfer, and immediately after embryo transfer.
In acupuncture group, the pregnancy rate was higher than placebo group (31% vs. 23%). Smith C. et al, Fertil Steril, 2006 May;85(5):1352-8 (Abstract here)
Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial
Women undergoing embryo transfer were devided to acupuncture group and no acupuncture group.
Acupuncture group received acpuncture on the day (ACU1 and ACU2) and 2 days later (ACU2) of embryo transfer.
Clinical and ongoing pregnancy rate were singnificantly highter in both acupuncture groups than control group.
Westergaard, L. G., et al, Fertil Steril, 2006 May;85(5) (Abstract here)